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When they knocked out the protein and stopped it from working, the cells were less round, and less able to grow and invade

Effects of grinding method on the compositional, physical, and functional properties of whole and split yellow pea flours

Although each model differs in terms of CAG repeat length and transgene expression levels, and thus in the severity of the resulting HD phenotype, they were instrumental in demonstrating a fundamental feature of the disease, namely that severe neuronal dysfunction precedes degeneration and it is probably the primary cause of many HD symptoms 8,9