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doi: 10.1093/jn/nxab280 83

RobinsonMGraySRWatsonMSKennedyGHillABelchJJFet al

(1) Omega-3 PUFAs (EPA/DHA) as core antidepressant components Deep-sea fish (e.g., salmon, mackerel) contain 23 g/100 g of EPA and DHA, which target two key pathways of depression: Inhibiting microglial activation: by inhibiting the NF-B/MAPK p38 signaling pathway and activating the neuronal BDNF-PI3K/AKT pathway, the process achieves a balance in microglial M1/M2 polarization and provides neuroprotection against neuroinflammation (313)

thus, autophagy enhancement may preserve fertility via P4 restoration, while inhibition in malignancies could disrupt progesterone-dependent survival circuits [182]

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However, this peptide has been on the World Anti-Doping Agency (WADA) prohibited list under Class S0 (Non-Approved Substances) since 2022