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TNF- upregulates epithelial adhesion molecules, promotes inflammatory cell recruitment and activation, and induces inflammatory mediator release, resulting in tissue damage [98]

Activating protein kinases like ATM ( Ataxia Telangiectasia Mutated ) and ATR ( ATM and Rad3-related ) is an integral part of this process because these kinases detect DNA damage and coordinate the repair of damaged DNA (Yan et al

Most chemical approaches aim to sensitise the tumour, but it is equally valid to seek radioprotective drugs which will selectively protect the normal cells

Ongoing research is targeting other areas of the body for treatment and the preliminary results are very encouraging

The model is the same as that in the previous tutorial

11 Thats especially relevant for women, since both estrogen and growth hormone decline with age, causing skin to become thinner and less elastic over time