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2.1 Eligibility criteria for this review This review includes umbrella meta-analyses evaluating the efficacy of nutritional supplementssuch as n-3 polyunsaturated fatty acids, alpha-lipoic acid, polyphenols, minerals, melatonin, vitamins, inositol, probiotics, and L-carnitinecompared to placebo or alternative treatments in women diagnosed with PCOS using the Rotterdam criteria (21)

At the molecular level, some of these compounds can modulate the expression and functionality of TJs proteins, which are critical for preserving the structural integrity of the BBB

Full estimates are demonstrated in Figure 3

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However, collagenases, enzymes within the matrix metalloproteinase (MMP) family, are among the few capable of cleaving intact fibrillar collagen [23]

The transcript abundance of the glutathione- S -transferases VviGST3 and VviGST4 and the -glutamyltranspeptidase ( VviGGT ), were similar between the control and the N100 treatment