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Vitamin B12 is the active corrinoid produced in cultivated white button mushrooms (Agaricus bisporus)

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The action of synthetic DMARDs is intracellular (Kiely and Nikiphorou 2018)

This immediately flags a common cause: Dietary Factors: Vegans and strict vegetarians are at a higher risk of deficiency if they dont consume fortified foods or supplements

Ferrous Fumarate and Polysaccharide Iron Complex (U.S