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Stability of the glucuronides to glucuronidase e.g, Phenylbutazone, Ethclorvinyl UGTAll glucuronides are cleaved C glucuronidesby glucuronidase except 23 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Two major human families of UGT UGT1 and UGT2 From: Guillemette et al., Drug Metab Rev, 2010 24 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 UGT Structure and Homology 25 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Biochemical pathways for cosubstrate UDPGAGlucose1P is derived from glycogen and the reactions are rapid, so cosubstrate depletion not often observed unless in starved animals.Cosubstrate depletion has been observed in animals with very large doses of drugs (e.g