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The early diagnosis of RA is often challenging due to the widespread symptoms reported by patients, including pain, swelling, stiffness, and functional impairment, many of which are also associated with other inflammatory diseases (Gibofsky 2014)

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The treatment of GSH results in increased enzymatic activities such as SOD, CAT, GPX, GR, MDHAR, and DHAR, which leads to an increase in endogenous AsA and GSH levels, along with increased ratios of AsA/DHA and GSH/GSSG, thus reducing the level of overproduced ROS species (Jung et al., 2019

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