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Depletion of USP11 inhibits cell proliferation and induces ROS-mediated stress-induced ferroptosis, an effect that can be mitigated by overexpression of NRF2

Cells were then incubated with or without cisplatin, etoposide (Cell Signaling Technologies, 2200S), doxorubicin (Sigma-Aldrich, D1515), staurosporin (Cell Signaling Technologies, 9953) or paclitaxel (Cell Signaling Technologies, 9807S) for an indicated period

However, there may be upregulation of succinate and aspartate (Zhou et al., 2018)

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Notably, the activity of SSAO in patients with diabetes is related to the risk factors of AS, such as obesity, total cholesterol, high blood pressure and blood sugar