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In summary, many environmental factors can activate oxidative pathway, which causes neurodegeneration

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10.1002/anie.202011157 177 SelfW

Studies have shown that diabetes, both type I and type II induce subtle molecular changes that are essential for sperm quality and function, but a follow up study by our team projected that the adverse effects caused by diabetes mellitus can partly be explained through the impact of OS, caused by the inequality between ROS production and antioxidant defense mechanisms (152)