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NADPH oxidase inhibition rescues keratinocytes from elevated oxidative stress in a 2D atopic dermatitis and psoriasis model

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J Pharmacol Exp Ther 328(3):866-72, 2009

It attacks the hydrogen atom of an amino acid residue to form a carbon-centered radical that reacts with oxygen to generate an alkyl-peroxyl radical and then in two steps an alkoxyl radical

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The formation of 8-OHdG, a modified nucleoside, is a consequence of oxidative DNA damage, particularly guanine residues (181)