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Hassani N, Jafari-Gharabaghlou D, Dadashpour M, et al

10.1016/0006-2952(94)90339-5 116 SeibtT

The first step is a routine eye exam

We gratefully acknowledge assistance from the UNSW Biological Resource Centre and Tzong-Tyng Hung from the Biological Resource Imaging Laboratory (BRIL) of the Mark Wainwright Analytical Centre, UNSW, which is a member of the National Imaging Facility, and the Bioanalytical Mass Spectrometry Facility of the Mark Wainwright Analytical Centre at UNSW

LHON is primarily caused by mtDNA mutations that affect complex I of the ETC, resulting in increased production of ROS and consequent mitochondrial dysfunction [123]