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Though Murcko scaffolding represents the skeleton of a molecule, it is possible that side chains may also play an important role in substrate recognition by the TolC-related efflux pumps that are not captured in the scaffold-based analysis

Antibiotic-resistant bacteria have emerged as a major problem, especially for hospital-acquired infections and the economic cost of multi-drug-resistant bacterial infections is immense

Arani N, Rausch CR, Geppner A, Borthakur G , Jain N, Ferrajoli A, Jabbour E, Sampath D, Hosing C, Vega F, Kantarjian HM, Kadia TM

10.1016/j.jff.2021.104661 9 B.CarlP.Patel (Editors) (2014)

The prepared C-Dots was quenched by Fe 3+ ion with a limit of detection of 0.32 M throughout a linear concentration (1100 M)

however, a remaining challenge is the ability to selectively induce ferroptosis in HSCs with minimal effects on healthy hepatocytes