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The specific pharmacokinetic parameters include the volume of distribution, half-life, mean residence time, maximum concentration, bioavailability, permeability, clearance, and area under the timeconcentration curve [434]

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Hence, this work gives an overview of the continuous efforts of researchers in this field mainly in the past five years, aimed at providing a broad reference for accelerating the development of stapled peptides as the next-generation therapeutic peptide drugs targeting various human diseases

Ponsero AJ, Igbaria A, Darch MA, Miled S, Outten CE, Winther JR, Palais G, D'Autreaux B, Delaunay-Moisan A, and Toledano MB

doi:10.2146/ajhp100452 82

K+ deficiency signaling is discussed next so it fits together