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555,556 Lifestyle modifications include head-up tilt sleeping, which elevates the head of the bed by 1030 to reduce nocturnal diuresis and improve morning orthostatic tolerance, and advising patients to avoid triggers such as prolonged standing, sudden postural changes, high ambient temperatures, and large meals that may exacerbate symptoms

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The exact cause of IBS is not fully understood, but it is believed to involve a combination of gut motility issues, inflammation, and sensitivity to various triggers

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They target distinct biological pathways, which is precisely why their combination (CagriSema) is under investigation offering broader metabolic coverage than either agent individually