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INTRODUCTION Harvey Cushing proposed in 1912 in his monograph The Pituitary Gland the existence of a hormone of growth and was thereby among the first to indicate that the primary action of growth hormone (GH) was to control and promote skeletal growth

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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GSH depletion is related to bioenergetic failure, with the later development of apoptotic processes