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Consistent with this, Awere et al

Performance is often evaluated in spiked buffer systems under controlled conditions rather than complex biological matrices containing interfering substances, variable pH, and protein fouling, which degrade sensor performance and reproducibility in clinical environments

Plasmin also activates pro-MMPs into active MMPs, further promoting ECM remodeling [185]

Simon, B., Madl, T., Mackereth, C

In this stage, toxins are bound to other substances, such as glutathione (an antioxidant) or amino acids, to make them less toxic and more water-soluble