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The review synthesized findings from cell-culture experiments (human dermal fibroblasts, keratinocytes, irradiated fibroblasts), animal models (rats, mice, pigs, dogs), and human cosmetic-science studies of topical formulations

FOXO4-DRI is a senolytic peptide developed at Erasmus University Medical Center by de Keizer et al

It binds with high affinity to hepatocyte growth factor (HGF) and amplifies HGFs activity at its receptor, c-Met

They retain the ability to interact with biological targets and produce similar biological effects

The NGS has received feedback from more than 745 county geospatial representatives

It is not an FDA-approved drug, so any clinical use is investigational and provider-supervised