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In another preferred embodiment, fingolimod, an analogue, metabolite or derivative thereof or a pharmaceutically acceptable salt thereof, and the other drug are provided as separate compositions for administration at the same time or at different times

2020 Nov 2;16:1047-1055

That's a real finding in real people and it matters, but the sample size, follow-up duration, and level of independent replication are in a different category from finasteride's evidence base

doi: 10.1126/science.abb8034 22 GiardiniV.CarrerA.CasatiM.ControE.VerganiP.Gambacorti-PasseriniC

Thus, trapping AP sites and blocking their repair by APE1 will result in cytotoxicity