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Notably, detection of VSRs themselves as PAMPs may evolve as a counter-counter-defense mechanism to trigger a non-canonical immune response (198), as also observed in plants (199)

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ROS show hyperpolarization of mitochondria and activated T lymphocytes [13, 14]

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183 The liver-specific Bmal1 -knockout mouse model ( Alb-Cre, Bmal1 fl/fl ) confirmed that this time-dependent hypoxic response strictly relies on a functionally intact tissue-intrinsic clock, rather than being solely regulated by systemic signals

These experiments provided a rationale for later mouse studies but did not establish a human fat-loss effect