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Wei Zhang, [email protected] This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Monosodium urate (MSU) crystals deposited in synovial tissue can interact with the innate immune system, triggering an inflammatory response that results in typical symptoms of gout, including pain, swelling, and redness [7]

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The active form of B12 in this formulation is methylated and, thus, highly bioavailable