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Notably, the hydroxyl group at the C4 position of the tetrahydropyran ring of substrate 7 also stabilizes the GSH-thiolate through an additional hydrogen bond (Extended Data Fig

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The results of functional enrichment analysis of differentially expressed proteins in the proteome revealed that the differentially expressed proteins were mainly enriched in cell components such as the cell membrane, mitochondria, mitochondrial membrane, and electron respiratory chain, etc(Fig