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High levels of glucocorticoids make neurons across the brain more susceptible to oxidative insults via well-described actions of glucocorticoids, including downregulating several antioxidant enzymes and increasing baseline levels of ROS production (ahin and Gml, 2004

10.1016/j.chembiol.2020.02.005 96 LiuP.FengY.LiH.ChenX.WangG.XuS.et al (2020b)

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4.4.2 Evidence of the effects of LOX on aging and senescence In general, LOX generates lipid hydroperoxides from PUFAs

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