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When assessing the interaction between TDP-43 and SUMO2/3, we observed a significant increase in interactions in the prefrontal cortex of ALS/FTD patients with TDP-43 pathology suggesting the TDP-43 SUMOylation pathway is engaged in disease (Fig

Notably, lipids were the largest class of metabolites found in the exometabolome (Fig

They are designed to dissolve slowly under the tongue, allowing for the medication to be absorbed through the oral mucosa directly into the bloodstream for systemic benefits or for local effects in the oral cavity

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Alan Castel, PhD, is a professor of psychology at the University of California, Los Angeles (UCLA) and one of the world's foremost experts on human memory and cognitive aging