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Nine randomized controlled trials (RCTs) revealed no evidence of adverse effects of rhGH on estimated GFR (eGFR) over treatment periods of up to 2 years in children with CKD stages 24 [171]

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The reason for this decrease is unclear since PSC activation (as assessed by -SMA staining) in this group was unchanged compared to other groups

doi: 10.1210/me.2010-0051 33 SinclairDWebsterMJWongJWeickertCS

A common feature in both forms of HRS is activation of the renin-angiotensin-aldosterone axis caused by intravascular volume depletion

*These values represent commonly encountered laboratory concentrations rather than universal recommendations