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Common variants of ABCG2 significantly accelerate the onset of hyperuricemia

doi: 10.1007/s00726-012-1226-x 111

considering that the glycolysis segment glycerol-3-phosphate 1,3-bisphosphoglycerate 3-phosphoglycerate (and downstream until phosphoenolpyruvate) is also reversible, interruption of the glycolytic pathway at the level of ALDO and/or above can be bypassed by provision of serine and glycine

Everything else is identical

This suggests that the interactions between IGF-1 LR3 and IGFBPs might determine the functional outcomes of IGF-1 LR3 in specific experimental contexts

Although their activity on a single target may be lower compared to single-target drugs, the synergistic effects of multi-target modulation result in a total effect greater than the sum of the individual effects, leading to better efficacy and fewer adverse reactions