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A., Stafylas, P

doi: 10.1023/a:1015593232347 122 ZhaoYLLiuWWLiuWLuZYXuanDHZhangXet al

1 Introduction The liver plays an important role in metabolic regulation, detoxification, and immune responses, making it highly susceptible to injury from external agents such as pharmaceuticals and environmental toxins

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How do different PTMs of NRF2 (ubiquitination, phosphorylation, acetylation) interact and compete during cellular stress responses, and what is their hierarchical relationship in regulating NRF2 activity

For example, Pulmozyme, a recombinant human DNase, is the most commonly used mucolytic for patients with cystic fibrosis to mitigate airway mucus obstruction