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Engineering Bacillus subtilis for high-value bioproduction: recent advances and applications

The B6-dependent enzymes cystathionine-beta-synthase (4.2.1.22) and cystathionine-gamma-lyase (4.4.1.1) metabolize homocysteine to L-cysteine, Figure 3

There are two main forms: CJC1295 with DAC (Drug Affinity Complex): Has a half-life of up to 8 days, allowing for just 12 weekly injections

Those observations of thiol oxidation are typically made on a time scale of hours to days

Injections are usually given as hydroxocobalamin or cyanocobalamin and are very effective in increasing blood B12 levels and preventing deficiency

Methods: Two cases of paroxysmal HCHB with video recording showing their abnormal movements