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Higher doses are reported to lower activity levels

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Naunyn Schmiedebergs Arch Pharmacol 385(1):6979

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Collectively, these data suggest that ArfGAP1 phosphorylation at these sites is required and sufficient for the synergistic interaction with G2019S LRRK2 in reducing neurite length, and blocking these sites (in the 3A mutant) can interfere with the neurite outgrowth deficits induced by G2019S LRRK2