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Ascorbate supplementation markedly improves the differentiation of midbrain derived neural stem cell against dopaminergic neurons, which is associated with the TET-mediated 5hmC generation and Jmjd3 catalyzed loss of H3K27m3 (He et al., 2015)

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LINK Tubbs RS, Johnson PC, Loukas M, Shoja MM, Cohen-Gadol AA: Anatomical landmarks for localizing the buccal branch of the trigeminal nerve on the face

doi: 10.1016/j.freeradbiomed.2021.01.025

It upregulates the expression of anti-inflammatory genes, including NF-BIA , MAP3K8 , and TLR5 , while concurrently downregulating pro-inflammatory genes such as TNFSF6 , TNF- , and nuclear factor-B ( NF-B ) [36,37,38,39]