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The application of controlled mechanical loads through resistance training can activate signaling pathways in fibroblasts, promoting collagen synthesis and strengthening the ACL

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Anti-inflammatory effects reduce swelling and pain, which supports faster functional recovery after strain or trauma

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Moreover, ablation of these genes leads to the complete absence of hypaxial muscles (diaphragm, limbs, tongue), reflecting that HGF-MET have a pivotal role in proliferation and motility of these muscle progenitors (Birchmeier and Gherardi, 1998)