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3.2 Clonal evolution and Darwinian selection under therapeutic pressure Beyond the selection of rare pre-existing resistant clones, therapeutic intervention itself functions as a powerful evolutionary force that reshapes tumor architecture through Darwinian selection

Park JH, Seo YH, Jang JH, Jeong CH, Lee S, Park B

2.2 Oxidative stress Oxidative stress induced by metabolic stress is closely associated with several pathological conditions, including mastitis, during the periparturient period in dairy cattle (26, 51, 52)

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In rat taste buds, caloric sugars were shown to augment cAMP concentrations, while non-caloric sweeteners mainly raised intracellular IP3 concentration (Striem et al., 1991