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10.1016/j.preteyeres.2022.101093 40

With time, this sustained elevated pressure becomes the new normal, predisposing the person to hypertension

Because heavy training often places stress on connective structures, compounds that interact with tissue signalling pathways attract significant interest

Cryan and O'Mahony, 2011

Bacterial metabolites such as butyrate further exacerbate PDLF ferroptosis by activating NCOA4dependent ferritinophagy, which mobilizes intracellular iron and promotes lipid peroxidation, thereby inhibiting PDLF proliferation and collagen production (51)