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Thus, the use of this approach allowed to identify an original target, the protein kinase DYRK1B, suggesting that an inhibitor of this protein could present a possible senolytic activity 40

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Topical GHK-Cu produces negligible systemic absorption transdermal bioavailability is less than 5% for unformulated aqueous solutions and rarely exceeds 1015% even with penetration enhancers like liposomes or DMSO