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doi: 10.1172/jci.insight.164813 56 GreeneM

33 Non-specific cysteine transporters While influx transporters are the main means by which cells acquire cystine, cysteine can also be taken up from the extracellular milieu into cells directly by excitatory amino acid transporter 3 (EAAT3) and the alanine-serine cysteine transporters 1 and 2 (ASCT1/2), all of which are known to be overexpressed in different cancer types 34 (Table 1)

The progressive neuronal loss, limited treatment efficacy, and enormous social and economic burden underscore the critical importance of early, targeted, and multi-mechanistic neuroprotective approaches