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IB is only phosphorylated by certain stimuli including LPS (lipopolysaccharide) and IL-1, whereas IB phosphorylation is triggered by most NF-B activators

Gut 65 , 144154 (2016)

Opportunities and challenges in targeting TDLNs LN-targeted immunotherapy As TDLNs are widely recognized for playing a key role in driving the immunotherapy response, it is hypothesized that the effectiveness of ICB relies predominantly on an influx of newly primed T cells into the tumor from peripheral lymphoid organs, particularly the TDLNs, rather than on reinvigorating exhausted and fully differentiated T cells that already exist in tumors (52)

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This product can be used on its own or in combination with another treatment