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Description

discovered that hyperglycemia affected endothelial function by increasing H 2 O 2 production, superoxide mitochondrial membrane polarization, and altering protein expression profiles associated with enzymes

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Struys-Ponsar, C

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Additionally, when considering cognitive decline caused by aging, dietary intake of caffeine can protect the brain by regulating the Bax/Bcl2 ratio, caspase-3, and PARP-1 levels to reduce oxidative stress, and COX-2, NOS-2, TNF, and IL-1 to further reduce D-galactose-induced neuroinflammation and neurodegeneration (Ullah et al., 2015)

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Its a story of immense promise that ultimately fell short of the specific, rigorous endpoints required for a commercial drug

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Ramming, T., Kanemura, S., Okumura, M., Inaba, K

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Its not just psychologicalits physiological

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