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Therefore, although our review aimed to broaden our knowledge on the clinical applications of ALA, further randomized, double-blind, placebo-controlled clinical trials with adequate sample sizes, homogeneity of population studied, statistical power, as well as longer duration are (still) needed to confirm the clinical benefit of this multifunctional compound and extend its use in routine medical practice

Fasting, calorie restriction, and exercise robustly activate these pathways and confer broad metabolic benefits

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Research focuses on: receptor-mediated growth signaling protein synthesis pathways systemic anabolic activity This distinction is central to their research applications

10.1021/acs.chemrestox.6b00191 83 QinX.PengY.ZhengJ

see also, Snijders et al., 2021)