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doi: 10.1016/j.semcancer.2022.02.012

BMI1 regulated proliferation and apoptosis of MSCs via repressing p16 INK4a expression

Notably, enzymes governing polyamine biosynthesis, including glutamic oxaloacetic transaminase 2 (GOT2), aminoacylase-1 (ACY1), ODC, and SDS, exhibit overexpression in prostate cancer, while ornithine aminotransferase (OAT) demonstrates insufficient expression (66)