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This ratio has been linked to body weight and fat deposition, indicating that obese people have a higher disproportionate ratio of these bacteria ( Bacteroidetes in the intestinal microbiota appears to be relevant in obesity, as obese people on a calorie-restricted diet lose weight and have a higher ratio of Bacteroidetes species in their gut microbiota ( 12.3 Diabetes Mellitus Insulin-dependent diabetes mellitus (IDDM)-related dysbiosis is marked by an increase in Bacteroidetes and Clostridium , as well as a reduction in mucin-degrading bacteria such as Bifidobacteria , Lactobacillus , and Prevotella ( Clostridium , an increase in Lactobacillus , and a reduction in Bacteroidetes