Hugh S Markus: nothing to disclose Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.07 - SMALL VESSEL DISEASE P329 - ESOC25-1687 CHOLINERGIC DISRUPTION CONTRIBUTES TO MOTORIC COGNITIVE DYSFUNCTION IN CEREBRAL SMALL VESSEL DISEASE Mengfei Cai 1,2 , Hao Li 1 , Milan Nemy 3,4 , Mina Jacob 1 , David Norris 5 , Marco Duering 6 , Yuhu Zhang 2 , Roy Kessels 5 , Lenka Vyslouzilova 4 , Stefan Teipel 7 , Daniel Ferreira Padilla 3,8 , Frank-Erik De Leeuw 1 , Anil Tuladhar 1 1 Department of Neurology, RadboudUMC, Nijmegen, Netherlands, 2 Guangdong Provincial Peoples Hospital (Guangdong Academy of Medical Sciences), Guangzhou, Netherlands, 3 Karolinska Institute, Stockholm, Sweden, 4 Czech Technical University in Prague, Prague, Czech Republic, 5 Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands, 6 University of Basel, Basel, Switzerland, 7 Rostock University Medical Center, Rostock, Germany, 8 Universidad Fernando Pessoa Canarias, Las Palmas, Spain Background and Aims: Cerebral small vessel disease (SVD) is a key vascular contributor to both cognitive and motor dysfunction, consequently leading to an increased risk of dementia, parkinsonism, and loss of functional independence
In a clinical study of 178 patients with chronic viral infections and high Epstein-Barr Virus (EBV) antibody titers, high-dose IV Vitamin C (7.550 g) led to significant reductions in antibody levels and symptom duration (Mikirova 2014)
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Magnesium improves insulin sensitivity, which supports stable blood sugar, by helping insulin bind to its receptor on cells and by moving glucose transport proteins to the cell surface
7,8 CGRP, which has emerged as a therapeutic target, acts on the trigeminovascular system, a complex system rich in CGRP and 5HT receptors that, as a potent vasodilator, causes the vascular changes originally observed in migraine
Glutathione transferase is the second line of defense against oxidative stress
