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Failure to diagnose and treat in time, however, may result in permanent neurological damage, excessive fatigue, depression, memory loss, and other complications

Metabolic cardiomyopathy is characterized by abnormalities within cardiomyocytes, such as excessive triacylglycerol accumulation and lipid toxicity injury, which can lead to diastolic dysfunction [218]

In particular, early-stage features such as gastrointestinal dysfunction, peripheral immune activation, and gradual -synuclein accumulation are often inadequately represented

Persistent unexplained elevation alongside an abnormal CBC or differential, constitutional symptoms such as unexplained weight loss, night sweats, or persistent fever, or organ-specific findings all raise the need for referral

We recruited a larger sample size (n = 19) for a 25% loss follow-up

Lancet 389 , 22872303 (2017)