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Goossens S, Vandamme N, Van Vlierberghe P, Berx G

Sci Rep (2021) 11:5493

It was suggested that the MITOLHMOX2 axis may respond to and maintain mitochondrial iron homeostasis, so we next generated HMOX1 KO cells, HMOX2 KO cells and DKO cells to determine the effect of HMOX on mitochondrial iron levels (Fig

In contrast to the potential resolution seen in AKI, the chronic inflammatory state in CKD fuels a detrimental cycle involving sustained immune cell activity, continuous release of pro-inflammatory and pro-fibrotic mediators, and progressive pathological tissue remodeling

Konopleva M, Mikhail A, Estrov Z, Zhao S, Harris D, Sanchez-Williams G, Kornblau SM , Jung J, Kliche KO, Jiang S, Przepiorka D, Snodgrass HR, Estey EH, Andreeff M