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The best way to prevent medication-induced RLS is to stop taking the causative drug

This marker is associated in several studies with an increased risk of coronary insufficiency, ischemic stroke, and peripheral arterial occlusive disease [65-67]

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AOD-9604 stimulates lipolysis and inhibits fat cell formation, CB4211 enhances insulin sensitivity and fatty acid metabolism, and Tesamorelin targets visceral fat through growth hormone-mediated pathways

So on the narrow question does it stop working after N weeks, the honest answer is: no published evidence says it does, and the mechanism actually argues against it

As we work at greater scale and with a wider range of clinicians, educational sessions and regular audit of our practice are key to maintaining this consistency