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In normal cells, P-glycoprotein, MRP1, ABCG2, and several other clinically relevant MRP-related drug transporters are often expressed in a polarized manner and contribute to drug absorption (bioavailability), distribution (limiting drug access to so-called pharmacological sanctuaries such as the brain, cerebral spinal fluid, and testes), and elimination (efflux into bile or urine) (Fig

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Enzo Spisni, [email protected] These authors have contributed equally to this work $ These authors have contributed equally to this work and share last authorship ORCID: Fabio Vivarelli, orcid.org/0000-0002-8734-0985 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This was particularly effecting memory and cognition coupled with previous positive tests to Epestine Barr, Cystic Acne and heavy metal toxicity

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