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Discontinuation rates due to adverse events remain low across studies (approximately 4-10%), indicating good overall tolerability

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10.1016/j.mrfmmm.2005.02.028 36 LlewellynW

Even though water retention should be taken to account, the numbers represent fat-free mass

(Some researchers believe that this is the primary therapeutic form of the drug because of its long persistence in the brain compared to fluoxetine.) Using the data from the Sunnybrook website [1] and taking the half-life to be 9 days for norfluoxetine, a reasonable model using linear kinetics for the blood plasma concentration of norfluoxetine is given by the equation N ( t ) = 27.5( e - 0.077 t - e - 0.462 t )

Magnesium, omega-3s, B-vitamins, and adaptogens like rhodiola often pair well