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Exercise capacity was determined by a single maximal exercise test to voluntary fatigue on a motorized treadmill (Exer 3/6, Columbus Instruments) in females [Young ( n = 10), Old Con ( n = 17), and Old mAb ( n = 22)] and males [Young ( n = 10), Old Con ( n = 9), and Old mAb ( n = 9)]

Mechanistically, SIRT1 may promote autophagy directly through its deacetylase activity on autophagy-related proteins, and indirectly through modulating upstream nutrient-sensing pathways such as AMPKmTORC1, depending on the cellular energy status and the availability of nicotinamide adenine dinucleotide + [7, 61, 62]

e467 (2018)

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Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis through histone acetylation and upregulation of Annexin A1 in AML1-ETO expressing Kasumi-1 cells