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Vitamin toxicity is another concern, especially with fat-soluble vitamins

CAFs upon activation secretes growth factors, cytokines, and ECM molecules including TGF-, matrix metalloproteinases (MMPs), hepatocyte growth factor (HGF), and fibroblast growth factors (FGFs), which are implicated in tumor development, invasion, and metastasis (120)

References Abdjul DB, Yamazaki H, Maarisit W et al (2017) Oleanane triterpenes with protein tyrosine phosphatase 1B inhibitory activity from aerial parts of Lantana camara collected in Indonesia and Japan

Effects of advanced glycation end products on differentiation and function of osteoblasts and osteoclasts

Moreover, the mRNA expression of Cntf and its receptor was found to be upregulated

This study demonstrates for the first time that VACV infection leads to the activation of the nuclear factor erythroid 2 (Nrf2)/antioxidant response element pathway, a key regulator of cellular antioxidant responses, a mechanism not previously described for any poxvirus