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This is why modulation of mGSH levels can influence disease progression, and therapies aimed at recovering mGSH levels may be of medical importance in numerous human diseases

SARS-CoV-2-infected patients with COVID-19 disease show alterations in the glucoseinsulin axis leading to hyperglycemia, hyperinsulinemia and insulin resistance, increased oxidative/nitrosative stress, and significantly decreased vitamin D, thiols, total-antioxidant-capacity, GSH and selenium (Soto et al., 2022)

Reversible glutathionylation is highly specic and the reactions occur in response to physiological/environmental stimuli [ 65 ]

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Moreover, studies in patients post-surgical for gall bladder procedures, revealed secretion of -tocopherol in bile is preferential, suggesting the liver distinguishes between - and -tocopherol secretion (Traber and Kayden, 1989)

Chemosensors 11 , 417 (2023)