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ALS is characterized by neurodegeneration of motor neurons in brain, spinal cord, and periphery, leading to progressive muscle paralysis: terminal events often comprise aspiration pneumonia and respiratory insufficiency (Morgan and Orrell, 2016

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Amminger GP, Berger GE, Schafer MR, Klier C, Friedrich MH, Feucht M

Since then, multiple PEGylated products including PEG-adenosine deaminase (ADA), interferons (IFN), human growth hormone (hGH), camptothecin (CPT) derivatives, recombinant human granulocyte colony-stimulating factor (rhG-CSF), and L-asparaginasehave been successfully commercialized and widely used in immunology, oncology, and related therapeutic areas