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Funding This study was supported by the Fund of National Key R&D Program of China (2021YFC2701700, 2021YFC2701704)

S2CID 13184375

OG and DG samples were applied as a 5% aqueous solution

The LDE detoxification impairment induced by FINO 2 and FIN56 was completely prevented by pre-treatment with the radical-trapping antioxidant (RTA) phenoxazine (PHOXN, Figure S2D ), similar to RSL3 as we previously demonstrated (36)

Then, with these phases, we carefully interrogated the active site nuclear density maps for visually distinct peroxide-derived species and protons on O or N atoms